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Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells

Loss of nuclear progesterone receptors (PR) and low circulating progesterone levels are associated with increased ovarian cancer (OC) risk. However, PR are abundantly expressed in a significant percentage of serous and endometrioid ovarian tumors; patients with PR+ tumors typically experience longer...

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Main Authors: Diep, Caroline H., Charles, Nathan J., Gilks, C. Blake, Kalloger, Steve E., Argenta, Peter A., Lange, Carol A.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674071/
https://ncbi.nlm.nih.gov/pubmed/23574718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24550
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