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LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence

Neuronal survival is dependent upon the retinoblastoma family members, Rb1 (Rb) and Rb2 (p130). Rb is thought to regulate gene repression, in part, through direct recruitment of chromatin modifying enzymes to its conserved LXCXE binding domain. We sought to examine the mechanisms that Rb employs to...

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Détails bibliographiques
Auteurs principaux: Andrusiak, Matthew G., Vandenbosch, Renaud, Dick, Fred A., Park, David S., Slack, Ruth S.
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674069/
https://ncbi.nlm.nih.gov/pubmed/23574720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24527
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