Effect of Single Amino Acid Substitution Observed in Cancer on Pim-1 Kinase Thermodynamic Stability and Structure

Pim-1 kinase, a serine/threonine protein kinase encoded by the pim proto-oncogene, is involved in several signalling pathways such as the regulation of cell cycle progression and apoptosis. Many cancer types show high expression levels of Pim kinases and particularly Pim-1 has been linked to the ini...

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Bibliografiske detaljer
Main Authors: Lori, Clorinda, Lantella, Antonella, Pasquo, Alessandra, Alexander, Leila T., Knapp, Stefan, Chiaraluce, Roberta, Consalvi, Valerio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673989/
https://ncbi.nlm.nih.gov/pubmed/23755147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064824
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