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Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability

Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lori, Laura, Pasquo, Alessandra, Lori, Clorinda, Petrosino, Maria, Chiaraluce, Roberta, Tallant, Cynthia, Knapp, Stefan, Consalvi, Valerio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942050/
https://ncbi.nlm.nih.gov/pubmed/27403962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159180
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