The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme

Cancer cells are able to survive in difficult conditions, reprogramming their metabolism according to their requirements. Under hypoxic conditions they shift from oxidative phosphorylation to aerobic glycolysis, a behavior known as Warburg effect. In the last years, glycolytic enzymes have been iden...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fiorillo, Annarita, Petrosino, Maria, Ilari, Andrea, Pasquo, Alessandra, Cipollone, Alessandra, Maggi, Maristella, Chiaraluce, Roberta, Consalvi, Valerio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040698/
https://ncbi.nlm.nih.gov/pubmed/29995887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199191
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