A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

Liver fibrosis is a reversible wound-healing response involving TGFβ1 activation of hepatic stellate cells (HSCs). Here we show that vitamin D receptor (VDR) ligands inhibit HSC activation and abrogate liver fibrosis, while Vdr knockout mice spontaneously developed hepatic fibrosis. Mechanistically,...

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Detalhes bibliográficos
Main Authors: Ding, Ning, Yu, Ruth T., Subramaniam, Nanthakumar, Sherman, Mara H., Wilson, Caroline, Rao, Renuka, Leblanc, Mathias, Coulter, Sally, He, Mingxiao, Scott, Christopher, Lau, Sue L., Atkins, Annette R., Barish, Grant D., Gunton, Jenny E., Liddle, Christopher, Downes, Michael, Evans, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673534/
https://ncbi.nlm.nih.gov/pubmed/23622244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.03.028
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