Association of a Single-Nucleotide Polymorphism in the Pregnane X Receptor (PXR 63396C→T) with Reduced Concentrations of Unboosted Atazanavir

This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T→C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02)....

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Autores principales: Siccardi, Marco, D’Avolio, Antonio, Baietto, Lorena, Gibbons, Sara, Sciandra, Mauro, Colucci, Daniela, Bonora, Stefano, Khoo, Saye, Back, David J., Di Perri, Giovanni, Owen, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672984/
https://ncbi.nlm.nih.gov/pubmed/18831695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/592304
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