Population Pharmacokinetic Modeling of the Association between 63396C→T Pregnane X Receptor Polymorphism and Unboosted Atazanavir Clearance

Atazanavir (ATV) plasma concentrations are influenced by CYP3A4 and ABCB1, which are regulated by the pregnane X receptor (PXR; NR1I2). PXR expression is correlated with CYP3A4 in liver in the absence of enzyme inducers. The PXR single nucleotide polymorphism (SNP) 63396C→T (rs2472677) alters PXR ex...

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Bibliografische gegevens
Hoofdauteurs: Schipani, Alessandro, Siccardi, Marco, D'Avolio, Antonio, Baietto, Lorena, Simiele, Marco, Bonora, Stefano, Rodríguez Novoa, Sonia, Cuenca, Lorena, Soriano, Vincent, Chierakul, Nitipatana, Saguenwong, Natpratou, Chuchuttaworn, Charoen, Hoskins, Janelle M., Dvorak, Anne M., McLeod, Howard L., Davies, Gerry, Khoo, Saye, Back, David J., Di Perri, Giovanni, Owen, Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2010
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981241/
https://ncbi.nlm.nih.gov/pubmed/20921307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00781-10
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