ロード中...

Population Pharmacokinetic Modeling of the Association between 63396C→T Pregnane X Receptor Polymorphism and Unboosted Atazanavir Clearance

Atazanavir (ATV) plasma concentrations are influenced by CYP3A4 and ABCB1, which are regulated by the pregnane X receptor (PXR; NR1I2). PXR expression is correlated with CYP3A4 in liver in the absence of enzyme inducers. The PXR single nucleotide polymorphism (SNP) 63396C→T (rs2472677) alters PXR ex...

詳細記述

保存先:
書誌詳細
主要な著者: Schipani, Alessandro, Siccardi, Marco, D'Avolio, Antonio, Baietto, Lorena, Simiele, Marco, Bonora, Stefano, Rodríguez Novoa, Sonia, Cuenca, Lorena, Soriano, Vincent, Chierakul, Nitipatana, Saguenwong, Natpratou, Chuchuttaworn, Charoen, Hoskins, Janelle M., Dvorak, Anne M., McLeod, Howard L., Davies, Gerry, Khoo, Saye, Back, David J., Di Perri, Giovanni, Owen, Andrew
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981241/
https://ncbi.nlm.nih.gov/pubmed/20921307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00781-10
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!