A Membrane-Translocating Peptide Penetrates into Bilayers without Significant Bilayer Perturbations

Using a high throughput screen, we have identified a family of 12-residue long peptides that spontaneously translocate across membranes. These peptides function by a poorly understood mechanism that is very different from that of the well-known, highly cationic cell penetrating peptides such as the...

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Bibliographische Detailangaben
Hauptverfasser: Cruz, Juan, Mihailescu, Mihaela, Wiedman, Greg, Herman, Katherine, Searson, Peter C., Wimley, William C., Hristova, Kalina
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2013
Schlagworte:
Membrane
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672899/
https://ncbi.nlm.nih.gov/pubmed/23746514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.043
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