Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis

INTRODUCTION: Systemic sclerosis (SSc) is more prevalent in women. Our goal is to determine the effects of 17β-estradiol (E2) on the development of fibrosis and to compare circulating levels of estrogens in SSc patients and healthy controls. METHODS: Using primary human dermal fibroblasts, we evalua...

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Autores principales: Aida-Yasuoka, Keiko, Peoples, Christine, Yasuoka, Hidekata, Hershberger, Pamela, Thiel, Katelynn, Cauley, Jane A, Medsger, Thomas A, Feghali-Bostwick, Carol A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672719/
https://ncbi.nlm.nih.gov/pubmed/23305385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4140
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