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The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis

Systemic sclerosis (SSc) is characterized by excessive fibrosis of the skin and internal organs due to fibroblast proliferation and excessive production of extracellular matrix (ECM). We have shown that insulin-like growth factor binding protein (IGFBP)-5 plays an important role in the development o...

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Bibliografiske detaljer
Main Authors: Yasuoka, Hidekata, Yamaguchi, Yukie, Feghali-Bostwick, Carol A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923757/
https://ncbi.nlm.nih.gov/pubmed/24551065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087754
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