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Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors

The phosphoinositide 3-kinase (PI3K) pathway serves as a relay where signals that emanate from the cell membrane are received and converted into intracellular signals that promote proliferation and survival. Inhibitors of PI3K hold promise for the treatment of breast cancer because activation of thi...

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Main Authors: Juvekar, Ashish, Wulf, Gerburg M
格式: Artigo
語言:Inglês
出版: BioMed Central 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672703/
https://ncbi.nlm.nih.gov/pubmed/23566381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3400
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