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Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Mutations in PIK3CA, encoding the insulin-activated phosphoinositide-3-kinase (PI3K), and loss of function mutations in PTEN, a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among the most frequent events in human cancers(1,2). Yet, pharmacological inhibition of PI3K h...

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Detaylı Bibliyografya
Yayımlandı:	Nature
Asıl Yazarlar:	Hopkins, Benjamin D., Pauli, Chantal, Du, Xing, Wang, Diana G., Li, Xiang, Wu, David, Amadiume, Solomon C., Goncalves, Marcus D., Hodakoski, Cindy, Lundquist, Mark R., Bareja, Rohan, Ma, Yan, Harris, Emily M., Sboner, Andrea, Beltran, Himisha, Rubin, Mark A., Mukherjee, Siddhartha, Cantley, Lewis C.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	2018
Konular:	Article
Online Erişim:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6197057/ https://ncbi.nlm.nih.gov/pubmed/30051890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0343-4
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Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

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