Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium

INTRODUCTION: Early pregnancy has a strong protective effect against breast cancer in humans and rodents, but the underlying mechanism is unknown. Because breast cancers are thought to arise from specific cell subpopulations of mammary epithelia, we studied the effect of parity on the transcriptome...

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Main Authors: Meier-Abt, Fabienne, Milani, Emanuela, Roloff, Tim, Brinkhaus, Heike, Duss, Stephan, Meyer, Dominique S, Klebba, Ina, Balwierz, Piotr J, van Nimwegen, Erik, Bentires-Alj, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672662/
https://ncbi.nlm.nih.gov/pubmed/23621987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3419
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