Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

INTRODUCTION: Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor-1 (PAR-1) is expressed by multiple cell types present in the lungs and can be activated by various proteases generated during acute inflammation. The cellular eff...

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Main Authors: Schouten, Marcel, van't Veer, Cornelis, Roelofs, Joris JTH, Levi, Marcel, van der Poll, Tom
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672627/
https://ncbi.nlm.nih.gov/pubmed/23270594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc11910
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