Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study

INTRODUCTION: Influenza accounts for 5 to 10% of community-acquired pneumonias and is a major cause of mortality. Sterile and bacterial lung injuries are associated with procoagulant and inflammatory derangements in the lungs. Activated protein C (APC) is an anticoagulant with anti-inflammatory prop...

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Main Authors: Schouten, Marcel, van der Sluijs, Koenraad F, Gerlitz, Bruce, Grinnell, Brian W, Roelofs, Joris JTH, Levi, Marcel M, van 't Veer, Cornelis, Poll, Tom van der
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887187/
https://ncbi.nlm.nih.gov/pubmed/20398279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8964
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