Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia

Pulmonary coagulopathy is intrinsic to pulmonary injury including pneumonia. Anticoagulant strategies could benefit patients with pneumonia, but systemic administration of anticoagulant agents may lead to suboptimal local levels and may cause systemic hemorrhage. We hypothesized nebulization to prov...

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Bibliographic Details
Published in:PLoS One
Main Authors: van den Boogaard, Florry E., Hofstra, Jorrit J., van ‘t Veer, Cornelis, Levi, Marcel M., Roelofs, Joris J. T. H., van der Poll, Tom, Schultz, Marcus J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436292/
https://ncbi.nlm.nih.gov/pubmed/25992779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127261
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