Repairing DNA damage by XRCC6/KU70 reverses TLR4-deficiency-worsened HCC development via restoring senescence and autophagic flux

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. The initiation and progression of HCC is closely associated with chronic liver inflammation. Recent research indicates that nonhomologous end joining (NHEJ), one of the DNA repair mechanisms, autop...

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Bibliographic Details
Main Authors: Wang, Ziyan, Lin, Heng, Hua, Fang, Hu, Zhuo-wei
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Autophagic Punctum
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672303/
https://ncbi.nlm.nih.gov/pubmed/23518600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.24229
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