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Immortalization of rat embryo fibroblasts by mutant polyomavirus large T antigens deficient in DNA binding.

We have identified a putative DNA-binding domain in polyomavirus large T antigen. Mutations introduced into the gene between amino acids 290 and 310 resulted in proteins that no longer bound to the high-affinity binding sites on the polyomavirus genome, showed no detectable nonspecific DNA binding,...

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Bibliografski detalji
Glavni autori: Cowie, A, de Villiers, J, Kamen, R
Format: Artigo
Jezik:Inglês
Izdano: 1986
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC367216/
https://ncbi.nlm.nih.gov/pubmed/3025653
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