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A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages
Oct4 is considered a master transcription factor for pluripotent cell self-renewal, but its biology remains poorly understood. Here, we investigated the role of Oct4 using the process of induced pluripotency. We found that a defined embryonic stem cell (ESC) level of Oct4 is required for pluripotenc...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671976/ https://ncbi.nlm.nih.gov/pubmed/23629142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2742 |
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