A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages

Oct4 is considered a master transcription factor for pluripotent cell self-renewal, but its biology remains poorly understood. Here, we investigated the role of Oct4 using the process of induced pluripotency. We found that a defined embryonic stem cell (ESC) level of Oct4 is required for pluripotenc...

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Main Authors: Radzisheuskaya, Aliaksandra, Chia, Gloryn Le Bin, dos Santos, Rodrigo L., Theunissen, Thorold W., Castro, L. Filipe C., Nichols, Jennifer, Silva, José C. R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671976/
https://ncbi.nlm.nih.gov/pubmed/23629142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2742
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