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Diverse Effects of Individual Mismatch Repair Components on Transcription-Induced CAG Repeat Instability in Human Cells

Several neurodegerative diseases are caused by expansion of a trinucleotide repeat tract in a critical gene. The mechanism of repeat instability is not yet defined, but in mice it requires MutSβ, a complex of MSH2 and MSH3. We showed previously that transcription through a CAG repeat tract induces r...

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Autori principali: Lin, Yunfu, Wilson, John H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671857/
https://ncbi.nlm.nih.gov/pubmed/19497791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.04.024
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