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Diverse Effects of Individual Mismatch Repair Components on Transcription-Induced CAG Repeat Instability in Human Cells
Several neurodegerative diseases are caused by expansion of a trinucleotide repeat tract in a critical gene. The mechanism of repeat instability is not yet defined, but in mice it requires MutSβ, a complex of MSH2 and MSH3. We showed previously that transcription through a CAG repeat tract induces r...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671857/ https://ncbi.nlm.nih.gov/pubmed/19497791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.04.024 |
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