Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin

Loss of the PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggr...

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Hauptverfasser: Vitolo, Michele I., Boggs, Amanda E., Whipple, Rebecca A., Yoon, Jennifer R., Thompson, Keyata, Matrone, Michael A., Cho, Edward H., Balzer, Eric M., Martin, Stuart S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671600/
https://ncbi.nlm.nih.gov/pubmed/22689060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.234
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