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Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin
Loss of the PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggr...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671600/ https://ncbi.nlm.nih.gov/pubmed/22689060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.234 |
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