Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice

Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usef...

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Autores principales: Iida, Asako, Takino, Naomi, Miyauchi, Hitomi, Shimazaki, Kuniko, Muramatsu, Shin-ichi
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671507/
https://ncbi.nlm.nih.gov/pubmed/23762870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/974819
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