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Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

Traditional antidepressants require many weeks to reveal their therapeutic effects. However, the widely replicated observation that a single subanesthetic dose of the NMDA glutamate receptor antagonist, ketamine, produced meaningful clinical improvement within hours suggested that rapidly acting ant...

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Detalhes bibliográficos
Main Authors: Krystal, John H., Sanacora, Gerard, Duman, Ronald S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671489/
https://ncbi.nlm.nih.gov/pubmed/23726151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.03.026
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