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The Neurobiology of Depression, Ketamine and Rapid-Acting Antidepressants: Is it Glutamate Inhibition or Activation?

The discovery of the antidepressant effects of ketamine has opened a breakthrough opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants (RAADs). In addition, the rapid and robust biological and behavioral effects of ketamine offered a unique opportunity to u...

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Detalhes bibliográficos
Publicado no:Pharmacol Ther
Main Authors: Abdallah, Chadi G., Sanacora, Gerard, Duman, Ronald S., Krystal, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165688/
https://ncbi.nlm.nih.gov/pubmed/29803629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2018.05.010
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