Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4–ALK-rearranged non–small–cell lung cancer harbored coexisting EGFR mutation

BACKGROUND: The EML4–ALK (echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene) fusion oncogene represents a novel molecular target in a small subset of non–small–cell lung cancers (NSCLCs). The EML4–ALK fusion gene occurs generally in NSCLC without mutations...

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Autors principals: Miyanaga, Akihiko, Shimizu, Kumi, Noro, Rintaro, Seike, Masahiro, Kitamura, Kazuhiro, Kosaihira, Seiji, Minegishi, Yuji, Shukuya, Takehito, Yoshimura, Akinobu, Kawamoto, Masashi, Tsuchiya, Shinichi, Hagiwara, Koichi, Soda, Manabu, Takeuchi, Kengo, Yamamoto, Nobuyuki, Mano, Hiroyuki, Ishikawa, Yuichi, Gemma, Akihiko
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Case Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671182/
https://ncbi.nlm.nih.gov/pubmed/23714228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-262
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