A mouse model for EML4-ALK-positive lung cancer

EML4-ALK is a fusion-type protein tyrosine kinase that is generated in human non-small-cell lung cancer (NSCLC) as a result of a recurrent chromosome inversion, inv (2)(p21p23). Although mouse 3T3 fibroblasts expressing human EML4-ALK form transformed foci in culture and s.c. tumors in nude mice, it...

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Hlavní autoři: Soda, Manabu, Takada, Shuji, Takeuchi, Kengo, Choi, Young Lim, Enomoto, Munehiro, Ueno, Toshihide, Haruta, Hidenori, Hamada, Toru, Yamashita, Yoshihiro, Ishikawa, Yuichi, Sugiyama, Yukihiko, Mano, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605003/
https://ncbi.nlm.nih.gov/pubmed/19064915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805381105
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