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Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation
RtcB is an atypical RNA ligase that joins either 2′,3′-cyclic phosphate or 3′-phosphate termini to 5′-hydroxyl termini. In contrast to typical RNA ligases, which rely on ATP and Mg(II), catalysis by RtcB is dependent on GTP and Mn(II) with ligation proceeding through a covalent RtcB–histidine–GMP in...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670941/ https://ncbi.nlm.nih.gov/pubmed/23560983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4002375 |
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