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Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation

RtcB is an atypical RNA ligase that joins either 2′,3′-cyclic phosphate or 3′-phosphate termini to 5′-hydroxyl termini. In contrast to typical RNA ligases, which rely on ATP and Mg(II), catalysis by RtcB is dependent on GTP and Mn(II) with ligation proceeding through a covalent RtcB–histidine–GMP in...

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Hlavní autoři: Desai, Kevin K., Bingman, Craig A., Phillips, George N., Raines, Ronald T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670941/
https://ncbi.nlm.nih.gov/pubmed/23560983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4002375
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