Cupric Ions Induce the Oxidation and Trigger the Aggregation of Human Superoxide Dismutase 1

BACKGROUND: Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD1), is a fatal degenerative disease of motor neurons. Because SOD1 is a major copper-binding protein present at relatively high concentration in motor neuron...

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Detalhes bibliográficos
Main Authors: Li, Cheng, Xu, Wen-Chang, Xie, Zhen-Sheng, Pan, Kai, Hu, Jiao, Chen, Jie, Pang, Dai-Wen, Yang, Fu-Quan, Liang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670862/
https://ncbi.nlm.nih.gov/pubmed/23755211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065287
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