αν and β1 Integrins Mediate Aβ-Induced Neurotoxicity in Hippocampal Neurons via the FAK Signaling Pathway

αν and β1 integrins mediate Aβ–induced neurotoxicity in primary hippocampal neurons. We treated hippocampal neurons with 2.5 µg/mL 17E6 and 5 µg/mL ab58524, which are specific αν and β1 integrin antagonists, respectively, for 42 h prior to 10 µM Aβ treatment. Next, we employed small interfering RNA...

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Bibliografiska uppgifter
Huvudupphovsmän: Han, Hai-Yan, Zhang, Jin-Ping, Ji, Su-Qiong, Liang, Qi-Ming, Kang, Hui-Cong, Tang, Rong-Hua, Zhu, Sui-Qiang, Xue, Zheng
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670848/
https://ncbi.nlm.nih.gov/pubmed/23755149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064839
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