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Recombination of homologous DNA fragments transfected into mammalian cells occurs predominantly by terminal pairing.

The mechanism by which double-strand cleavages stimulate the joining of plasmid DNA fragments introduced into cultured mammalian cells was investigated by cotransfecting pairs of plasmids encoding deletion mutations in a dominant selectable gene into LMtk- cells. Plasmid recombination substrates wer...

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Библиографические подробности
Главные авторы: Anderson, R A, Eliason, S L
Формат: Artigo
Язык:Inglês
Опубликовано: 1986
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC367062/
https://ncbi.nlm.nih.gov/pubmed/3023971
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