Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Cancer cell growth requires fatty acids to replicate cellular membranes. The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1. We used (13)C tracers and lipidomics to probe fatty acid metaboli...

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Hauptverfasser: Kamphorst, Jurre J., Cross, Justin R., Fan, Jing, de Stanchina, Elisa, Mathew, Robin, White, Eileen P., Thompson, Craig B., Rabinowitz, Joshua D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670379/
https://ncbi.nlm.nih.gov/pubmed/23671091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307237110
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