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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Cancer cell growth requires fatty acids to replicate cellular membranes. The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1. We used (13)C tracers and lipidomics to probe fatty acid metaboli...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670379/ https://ncbi.nlm.nih.gov/pubmed/23671091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307237110 |
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