Genomic hypomethylation and far-5' sequence alterations are associated with carcinogen-induced activation of the hamster thymidine kinase gene.

We have investigated the mechanism of activation of an inactive but functionally intact hamster thymidine kinase (TK) gene by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. Following carcinogen treatment of TK- RJK92 Chinese hamster cells, aminopterin-resistant (HATr) colonies ap...

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Bibliographic Details
Main Authors: Barr, F G, Rajagopalan, S, MacArthur, C A, Lieberman, M W
Format: Artigo
Language:Inglês
Published: 1986
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC367036/
https://ncbi.nlm.nih.gov/pubmed/3785222
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