Genomic hypomethylation and far-5' sequence alterations are associated with carcinogen-induced activation of the hamster thymidine kinase gene.

We have investigated the mechanism of activation of an inactive but functionally intact hamster thymidine kinase (TK) gene by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. Following carcinogen treatment of TK- RJK92 Chinese hamster cells, aminopterin-resistant (HATr) colonies appeare...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Barr, F G, Rajagopalan, S, MacArthur, C A, Lieberman, M W
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1986
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367036/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3785222/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.9.3023-3033.1986
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