IL-1β/HMGB1 Complexes Promote The PGE(2) Biosynthesis Pathway in Synovial Fibroblasts

PGE(2) is a potent lipid mediator of pain and oedema found elevated in RA. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme of the PGE(2) pathway inducible by proinflammatory cytokines. mPGES-1 is markedly upregulated in RA synovial tissue despite antirheumatic treatments, sugges...

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Detalhes bibliográficos
Main Authors: Leclerc, P, Wähämaa, H, Idborg, H, Jakobsson, P J, Harris, H E, Korotkova, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Experimental Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670302/
https://ncbi.nlm.nih.gov/pubmed/23488692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/sji.12041
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