High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

INTRODUCTION: In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopolysaccharide (LPS), CpG-DNA and IL-1β, through the formation of complexes. Ext...

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Main Authors: Wähämaa, Heidi, Schierbeck, Hanna, Hreggvidsdottir, Hulda S, Palmblad, Karin, Aveberger, Anne-Charlotte, Andersson, Ulf, Harris, Helena Erlandsson
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239379/
https://ncbi.nlm.nih.gov/pubmed/21871094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3450
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