Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

Cycloserine (CS, 4-amino-3-isoxazolidone) is a cyclic amino acid mimic that is known to inhibit many essential pyridoxal 5′-phosphate (PLP)-dependent enzymes. Two CS enantiomers are known; d-cycloserine (DCS, also known as Seromycin), is a natural product that is used to treat resistant Mycobacteriu...

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Main Authors: Lowther, Jonathan, Yard, Beverley A., Johnson, Kenneth A., Carter, Lester G., Bhat, Venugopal T., Raman, Marine C. C., Clarke, David J., Ramakers, Britta, McMahon, Stephen A., Naismith, James H., Campopiano, Dominic J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670083/
https://ncbi.nlm.nih.gov/pubmed/20445930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c003743e
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