Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria

BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g. nontypeable Haemophilus influenzae [NTHi]) infection. However, th...

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Hauptverfasser: Jiang, Di, Wenzel, Sally E., Wu, Qun, Bowler, Russell P., Schnell, Christina, Chu, Hong Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669426/
https://ncbi.nlm.nih.gov/pubmed/23741370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064689
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