RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, and is aberrantly activated in human cancer. As such, numerous compounds targeting the PI3K pathway are currently being clinically evaluated for the treatment of cancer, and several ha...

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Main Authors: Serra, Violeta, Eichhorn, Pieter J.A., García-García, Celina, Ibrahim, Yasir H., Prudkin, Ludmila, Sánchez, Gertrudis, Rodríguez, Olga, Antón, Pilar, Parra, Josep-Lluís, Marlow, Sara, Scaltriti, Maurizio, Pérez-Garcia, José, Prat, Aleix, Arribas, Joaquín, Hahn, William C., Kim, So Young, Baselga, José
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668839/
https://ncbi.nlm.nih.gov/pubmed/23635776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66343
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