RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, and is aberrantly activated in human cancer. As such, numerous compounds targeting the PI3K pathway are currently being clinically evaluated for the treatment of cancer, and several ha...

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Detalhes bibliográficos
Main Authors: Serra, Violeta, Eichhorn, Pieter J.A., García-García, Celina, Ibrahim, Yasir H., Prudkin, Ludmila, Sánchez, Gertrudis, Rodríguez, Olga, Antón, Pilar, Parra, Josep-Lluís, Marlow, Sara, Scaltriti, Maurizio, Pérez-Garcia, José, Prat, Aleix, Arribas, Joaquín, Hahn, William C., Kim, So Young, Baselga, José
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668839/
https://ncbi.nlm.nih.gov/pubmed/23635776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66343
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