Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

JAK2 activity is tightly controlled through a self-inhibitory effect via its JAK homology domain 2 (JH2), which restricts the strength and duration of JAK2/STAT3 signaling under physiological conditions. Although multiple mutations within JAK2, which abrogate the function of JH2 and sustain JAK2 act...

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Autori principali: Chen, Xiuting, Ying, Zhe, Lin, Xi, Lin, Huanxin, Wu, Jueheng, Li, Mengfeng, Song, Libing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668815/
https://ncbi.nlm.nih.gov/pubmed/23676499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68143
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