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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
JAK2 activity is tightly controlled through a self-inhibitory effect via its JAK homology domain 2 (JH2), which restricts the strength and duration of JAK2/STAT3 signaling under physiological conditions. Although multiple mutations within JAK2, which abrogate the function of JH2 and sustain JAK2 act...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3668815/ https://ncbi.nlm.nih.gov/pubmed/23676499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68143 |
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