NK cells impede glioblastoma virotherapy via NKp30 and NKp46 natural cytotoxicity receptors

The role of the immune response to oncolytic Herpes Simplex viral (oHSV) therapy for glioblastoma is controversial. Within hours of oHSV infection of human or syngeneic glioblastoma in mice, activated natural killer (NK) cells are recruited to the site of infection. This response significantly dimin...

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Autors principals: Alvarez-Breckenridge, Christopher A., Yu, Jianhua, Price, Richard, Wojton, Jeffrey, Pradarelli, Jason, Mao, Hsiaoyin, Wei, Min, Wang, Yan, He, Shun, Hardcastle, Jayson, Fernandez, Soledad A., Kaur, Balveen, Lawler, Sean E, Vivier, Eric, Mandelboim, Ofer, Moretta, Alessandro, Caligiuri, Michael A., Chiocca, E Antonio
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668784/
https://ncbi.nlm.nih.gov/pubmed/23178246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3013
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