NK cells impede glioblastoma virotherapy via NKp30 and NKp46 natural cytotoxicity receptors

The role of the immune response to oncolytic Herpes Simplex viral (oHSV) therapy for glioblastoma is controversial. Within hours of oHSV infection of human or syngeneic glioblastoma in mice, activated natural killer (NK) cells are recruited to the site of infection. This response significantly dimin...

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Huvudupphovsmän: Alvarez-Breckenridge, Christopher A., Yu, Jianhua, Price, Richard, Wojton, Jeffrey, Pradarelli, Jason, Mao, Hsiaoyin, Wei, Min, Wang, Yan, He, Shun, Hardcastle, Jayson, Fernandez, Soledad A., Kaur, Balveen, Lawler, Sean E, Vivier, Eric, Mandelboim, Ofer, Moretta, Alessandro, Caligiuri, Michael A., Chiocca, E Antonio
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668784/
https://ncbi.nlm.nih.gov/pubmed/23178246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3013
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