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Ataxia Telangiectasia-mutated- and Rad3-related Protein Regulates the DNA Damage-induced G(2)/M Checkpoint through the Aurora A Cofactor Bora Protein

Polo-like kinase1 (Plk1) activation is inhibited in response to DNA damage, and this inhibition contributes to the activation of the G(2)/M checkpoint, although the molecular mechanism by which Plk1 is inhibited is not clear. Here we report that the DNA damage signaling pathway inhibits Plk1 activit...

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Detalles Bibliográficos
Main Authors: Qin, Bo, Gao, Bowen, Yu, Jia, Yuan, Jian, Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668769/
https://ncbi.nlm.nih.gov/pubmed/23592782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.456780
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