Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in silico models

BACKGROUND: The Multidrug Resistance Protein ABCC11/MRP8 is expressed in physiological barriers and tumor breast tissues in which it secretes various substrates including cGMP (cyclic guanosine monophosphate) and 5FdUMP (5-fluoro-2′-deoxyuridine-5′-monophosphate), the active metabolite of the antica...

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Hlavní autoři: Honorat, Mylène, Terreux, Raphaël, Falson, Pierre, Di Pietro, Attilio, Dumontet, Charles, Payen, Lea
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668285/
https://ncbi.nlm.nih.gov/pubmed/23641929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-13-7
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