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EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumo...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Landes Bioscience
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3667899/ https://ncbi.nlm.nih.gov/pubmed/23762793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24052 |
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